1627 Dermal fibroblast cells respond differently to UVA and retinol treatments based on age and ethnicity

Aging comprises of two synergistic processes: intrinsic or chronologic aging, and extrinsic aging. Ultraviolet (UV) radiation is the main accelerator skin ageing, inducing production reactive oxygen species (ROS) pro-inflammatory mediators in cells. Retinol gold standard anti-aging treatments. As part a multi-decade ethnicity study, we studied human skin’s response either to UVA exposure an enhanced retinol-complex treatment. Caucasian fibroblasts from four age groups, ranging 18 60+ years old were treated with UVA, generated ROS measured before after Fibroblasts young groups displayed lower endogenous levels but showed higher UVA-induced generation than older-age Comparatively, African American ROS, less skin. When retinol-complex, younger (ages 18-25) 3 6 times more responsive older 50-60+). Human explants obtained subjects equally topical stabilized retinol Taken together, this work revealed new insights on responses treatment vs diverse types. These will enable effective personalized towards for